JAK-STAT

JAK-STAT pathway and JAK inhibitors: a primer for dermatologists

Background: All cellular events depend upon the DNA synthesis and gene expression involving complex interplay between ligands such as interleukins and interferons, with various cell membrane receptors. These ligand-receptors interactions transmit signals within the cell via numerous signal transduction pathways to affect gene expression. Janus kinase/signal transducer and activator of transcrip...

Jak-stat

90 JAK-STAT Volume 1 issue 2 In this issue of JAK-STAT, we introduce a series of reviews overlooking the ever-expanding field of myocardial JAK-STAT signaling. The history of cardiac JAK-STAT research begins in the mid-nineties, when various groups began to focus their attention on how myocardial physiology was specifically regulated through JAK-STAT signaling. Interest in the area began to gro...

JAK-STAT and feeding

The regulation of energy balance requires a complex system to homeostatically maintain the adult body at a precise set point. The central nervous system, particularly the hypothalamus, plays a key role in integrating a variety of signals that can relay information about the body's energy stores. As part of this system, numerous cytokines and hormones contribute to the regulation of food intake ...

SnapShot: JAK-STAT Signaling

A JAK/STAT invasion

and colleagues have identified a protein called Hippi as one possible mediator of Huntington disease (HD) neuronal cell death. HD begins with expansion of the polyglutamine repeats in the huntingtin protein (Htt). This frees up Hip1 protein, which normally binds to Htt. Free Hip1 can then bind to the Hippi protein identified by Nicholson, and the two proteins join in a complex with procaspase 8...